Anti-BACE2 nanobody [SAA0876] (STJN000320)

SKU:
STJN000320
$510.98 - $2,203.88
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Beta-Secretase 2 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA0876
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: BACE2
Gene ID: 25825
Uniprot ID: BACE2_HUMAN
Post Translational Modifications Undergoes autoproteolytic cleavage. Glycosylated.
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Protein Name Beta-Secretase 2
Aspartic-Like Protease 56 Kda
Aspartyl Protease 1
Asp1
Asp 1
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2
Beta-Site App Cleaving Enzyme 2
Down Region Aspartic Protease
Drap
Memapsin-1
Membrane-Associated Aspartic Protease 1
Theta-Secretase
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Endoplasmic Reticulum
Endosome
Melanosome
Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Nanobody Names Anti-Beta-Secretase 2 nanobody
Anti-Aspartic-Like Protease 56 Kda nanobody
Anti-Aspartyl Protease 1 nanobody
Anti-Asp1 nanobody
Anti-Asp 1 nanobody
Anti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 nanobody
Anti-Beta-Site App Cleaving Enzyme 2 nanobody
Anti-Down Region Aspartic Protease nanobody
Anti-Drap nanobody
Anti-Memapsin-1 nanobody
Anti-Membrane-Associated Aspartic Protease 1 nanobody
Anti-Theta-Secretase nanobody
Anti-BACE2 nanobody
Anti-AEPLC nanobody
Anti-ALP56 nanobody
Anti-ASP21 nanobody
Anti-CDA13 nanobody
Anti-UNQ418 nanobody
Anti-PRO852 nanobody

Information sourced from Uniprot.org