| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Nanobody Names | Anti-Beta-Secretase 2 nanobodyAnti-Aspartic-Like Protease 56 Kda nanobodyAnti-Aspartyl Protease 1 nanobodyAnti-Asp1 nanobodyAnti-Asp 1 nanobodyAnti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 nanobodyAnti-Beta-Site App Cleaving Enzyme 2 nanobodyAnti-Down Region Aspartic Protease nanobodyAnti-Drap nanobodyAnti-Memapsin-1 nanobodyAnti-Membrane-Associated Aspartic Protease 1 nanobodyAnti-Theta-Secretase nanobodyAnti-BACE2 nanobodyAnti-AEPLC nanobodyAnti-ALP56 nanobodyAnti-ASP21 nanobodyAnti-CDA13 nanobodyAnti-UNQ418 nanobodyAnti-PRO852 nanobody |
Information sourced from Uniprot.org
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