| Tissue Specificity | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). Isoform 1: Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil). Isoform 2: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-9927354 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Icos Ligand antibodyAnti-B7 Homolog 2 antibodyAnti-B7-H2 antibodyAnti-B7-Like Protein Gl50 antibodyAnti-B7-Related Protein 1 antibodyAnti-B7rp-1 antibodyAnti-Cd Antigen Cd275 antibodyAnti-ICOSLG antibodyAnti-B7H2 antibodyAnti-B7RP1 antibodyAnti-ICOSL antibodyAnti-KIAA0653 antibody |
Information sourced from Uniprot.org
