| Host: | Rabbit |
| Applications: | WB/IHC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Beta-1-4-Glucuronyltransferase 1 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 1.9 mg/mL |
| Dilution Range: | WB 1:1000-1:5000, IHC 1:50-1:300 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | B4GAT1 |
| Gene ID: | 11041 |
| Uniprot ID: | B4GA1_HUMAN |
| Immunogen: | Synthetic peptide of human B4GAT1 |
| Tissue Specificity | In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocytes. In fetal highly expressed in brain and kidney and to a lesser extent in lung and liver. |
| Function | Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance.via its function in O-mannosylation of alpha-dystroglycan (DAG1). |
| Protein Name | Beta-1 -4-Glucuronyltransferase 1 I-Beta-1 -3-N-Acetylglucosaminyltransferase Ignt N-Acetyllactosaminide Beta-1 -3-N-Acetylglucosaminyltransferase Poly-N-Acetyllactosamine Extension Enzyme Udp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1 |
| Database Links | Reactome: R-HSA-2022854 Reactome: R-HSA-5083627 Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus Membrane Single-Pass Type Ii Membrane Protein Localizes Near The Trans-Golgi Apparatus |
| Alternative Antibody Names | Anti-Beta-1 -4-Glucuronyltransferase 1 antibody Anti-I-Beta-1 -3-N-Acetylglucosaminyltransferase antibody Anti-Ignt antibody Anti-N-Acetyllactosaminide Beta-1 -3-N-Acetylglucosaminyltransferase antibody Anti-Poly-N-Acetyllactosamine Extension Enzyme antibody Anti-Udp-Glcnac -Betagal Beta-1 -3-N-Acetylglucosaminyltransferase 1 antibody Anti-B4GAT1 antibody Anti-B3GNT1 antibody Anti-B3GNT6 antibody |
Information sourced from Uniprot.org