![Anti-B2M/Beta-2-microglobulin nanobody [SAA1171] (STJN000543)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/201156/413254/STJN000543-SDS-PAGE-1__43808.1749232740.jpg?c=1 "Anti-B2M/Beta-2-microglobulin nanobody [SAA1171] (STJN000543)")
![Anti-B2M/Beta-2-microglobulin nanobody [SAA1171] (STJN000543)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/201156/413254/STJN000543-SDS-PAGE-1__43808.1749232740.jpg?c=1 "Anti-B2M/Beta-2-microglobulin nanobody [SAA1171] (STJN000543)")
| Host: | Alpaca |
| Applications: | ELISA/SPR |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Alpaca monoclonal nanobody anti-Beta-2-Microglobulin Cleaved Into-Beta-2-Microglobulin Form Pi 5.3 is suitable for use in ELISA and SPR research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA1171 |
| Conjugation: | Unconjugated |
| Isotype: | VHH-8His-Cys-tag |
| Formulation: | 0.01M PBS, pH 7.4. |
| Purification: | Purified by Nickel column. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Gene Symbol: | B2M |
| Gene ID: | 567 |
| Uniprot ID: | B2MG_HUMAN |
| Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation. |
| Protein Name | Beta-2-Microglobulin Cleaved Into - Beta-2-Microglobulin Form Pi 5.3 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1236977Reactome: R-HSA-164940Reactome: R-HSA-198933Reactome: R-HSA-2172127Reactome: R-HSA-2424491Reactome: R-HSA-6798695Reactome: R-HSA-877300Reactome: R-HSA-9637628Reactome: R-HSA-9705671Reactome: R-HSA-977225Reactome: R-HSA-983170 |
| Cellular Localisation | SecretedCell SurfaceDetected In Serum And Urine(Microbial Infection) In The Presence Of MTuberculosis Esxa-Esxb Complex Decreased Amounts Of B2m Are Found On The Cell Surface |
| Alternative Nanobody Names | Anti-Beta-2-Microglobulin Cleaved Into - Beta-2-Microglobulin Form Pi 5.3 nanobodyAnti-B2M nanobodyAnti-CDABP0092 nanobodyAnti-HDCMA22P nanobody |
Information sourced from Uniprot.org