| Tissue Specificity | Widely expressed. Abundant expression seen in the pancreas and testis. |
| Post Translational Modifications | Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation. |
| Function | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. |
| Protein Name | 5-Azacytidine-Induced Protein 2Nf-Kappa-B-Activating Kinase-Associated Protein 1Nak-Associated Protein 1Nap1Tilp |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-5-Azacytidine-Induced Protein 2 antibodyAnti-Nf-Kappa-B-Activating Kinase-Associated Protein 1 antibodyAnti-Nak-Associated Protein 1 antibodyAnti-Nap1 antibodyAnti-Tilp antibodyAnti-AZI2 antibodyAnti-NAP1 antibodyAnti-TBKBP2 antibody |
Information sourced from Uniprot.org
