Anti-AXIN2 antibody (800-843) (STJ500195)

Name: Anti-AXIN2 antibody (800-843) (STJ500195)
SKU: STJ500195-100
Price: 552.69 USD
Availability: InStock

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SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.

STJ500195-100

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Short Description	Rabbit polyclonal antibody anti-AXIN2 (800-843) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IHC/IP/WB
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	0.65 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:100
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	AXIN2
Gene ID	8313
Uniprot ID	AXIN2_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.
Immunogen Region	800-843

Tissue Specificity	Expressed in brain and lymphoblast.
Post Translational Modifications	Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function	Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Protein Name	Axin-2 Axin-Like Protein Axil Axis Inhibition Protein 2 Conductin
Database Links	Reactome: R-HSA-201681 Reactome: R-HSA-4411364 Reactome: R-HSA-4641257 Reactome: R-HSA-5689880
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Axin-2 antibody Anti-Axin-Like Protein antibody Anti-Axil antibody Anti-Axis Inhibition Protein 2 antibody Anti-Conductin antibody Anti-AXIN2 antibody

Information sourced from Uniprot.org