• Immunohistochemistry analysis of paraffin-embedded human testis tissue, using ATP7B Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using ATP7B Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-ATP7B antibody (161-210 aa) (STJ91777)

SKU:
STJ91777

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Copper-transporting ATPase 2 (161-210 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP7B
Gene ID: 540
Uniprot ID: ATP7B_HUMAN
Immunogen Region: 161-210 aa
Specificity: ATP7B Polyclonal Antibody detects endogenous levels of ATP7B protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ATP7B at the amino acid range 161-210
Post Translational Modifications Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
Function Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
Protein Name Copper-Transporting Atpase 2
Copper Pump 2
Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda
Database Links Reactome: R-HSA-936837
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Late Endosome
Predominantly Found In The Trans-Golgi Network (Tgn)
Localized In The Trans-Golgi Network Under Low Copper Conditions
Redistributes To Cytoplasmic Vesicles When Cells Are Exposed To Elevated Copper Levels
And Then Recycles Back To The Trans-Golgi Network When Copper Is Removed
Isoform 1: Golgi Apparatus Membrane
Isoform 2: Cytoplasm
Wnd/140 Kda: Mitochondrion
Alternative Antibody Names Anti-Copper-Transporting Atpase 2 antibody
Anti-Copper Pump 2 antibody
Anti-Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda antibody
Anti-ATP7B antibody
Anti-PWD antibody
Anti-WC1 antibody
Anti-WND antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance