| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP6V1A (500-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATP6V1A |
| Gene ID: |
523 |
| Uniprot ID: |
VATA_HUMAN |
| Immunogen Region: |
500-600 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ATP6V1A (NP_001681.2). |
| Immunogen Sequence: |
SLAETDKITLEVAKLIKDDF LQQNGYTPYDRFCPFYKTVG MLSNMIAFYDMARRAVETTA QSDNKITWSIIREHMGDILY KLSSMKFKDPLKDGEAKIKS D |
| Tissue Specificity | High expression in the skin. |
| Post Translational Modifications | Phosphorylation at Ser-384 by AMPK down-regulates its enzyme activity. |
| Function | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction. |
| Protein Name | V-Type Proton Atpase Catalytic Subunit AV-Atpase Subunit AV-Atpase 69 Kda SubunitVacuolar Atpase Isoform Va68Vacuolar Proton Pump Subunit Alpha |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | CytoplasmCytosolCytoplasmic VesicleSecretory VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinLysosomeCo-Localizes With Wfs1 In The Secretory Granules In Neuroblastoma Cell Lines |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Catalytic Subunit A antibodyAnti-V-Atpase Subunit A antibodyAnti-V-Atpase 69 Kda Subunit antibodyAnti-Vacuolar Atpase Isoform Va68 antibodyAnti-Vacuolar Proton Pump Subunit Alpha antibodyAnti-ATP6V1A antibodyAnti-ATP6A1 antibodyAnti-ATP6V1A1 antibodyAnti-VPP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
