| Tissue Specificity | Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. |
| Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
| Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
| Protein Name | Renin ReceptorAtpase H(+-Transporting Lysosomal Accessory Protein 2Atpase H(+-Transporting Lysosomal-Interacting Protein 2Er-Localized Type I Transmembrane AdapterEmbryonic Liver Differentiation Factor 10N14fRenin/Prorenin ReceptorVacuolar Atp Synthase Membrane Sector-Associated Protein M8-9Atp6m8-9V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCytoplasmic VesicleAutophagosome MembraneCell ProjectionDendritic Spine MembraneAxonEndosome MembraneClathrin-Coated Vesicle MembraneSecretory VesicleSynaptic Vesicle Membrane |
| Alternative Antibody Names | Anti-Renin Receptor antibodyAnti-Atpase H(+-Transporting Lysosomal Accessory Protein 2 antibodyAnti-Atpase H(+-Transporting Lysosomal-Interacting Protein 2 antibodyAnti-Er-Localized Type I Transmembrane Adapter antibodyAnti-Embryonic Liver Differentiation Factor 10 antibodyAnti-N14f antibodyAnti-Renin/Prorenin Receptor antibodyAnti-Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 antibodyAnti-Atp6m8-9 antibodyAnti-V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment antibodyAnti-ATP6AP2 antibodyAnti-ATP6IP2 antibodyAnti-CAPER antibodyAnti-ELDF10 antibodyAnti-HT028 antibodyAnti-MSTP009 antibodyAnti-PSEC0072 antibody |
Information sourced from Uniprot.org
