| Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
| Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
| Protein Name | Renin ReceptorAtpase H(+-Transporting Lysosomal Accessory Protein 2Atpase H(+-Transporting Lysosomal-Interacting Protein 2Er-Localized Type I Transmembrane AdapterEmbryonic Liver Differentiation Factor 10N14fRenin/Prorenin ReceptorVacuolar Atp Synthase Membrane Sector-Associated Protein M8-9Atp6m8-9V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCytoplasmic VesicleAutophagosome MembraneCell ProjectionDendritic Spine MembraneAxonEndosome MembraneClathrin-Coated Vesicle MembraneSecretory VesicleSynaptic Vesicle Membrane |
| Alternative Antibody Names | Anti-Renin Receptor antibodyAnti-Atpase H(+-Transporting Lysosomal Accessory Protein 2 antibodyAnti-Atpase H(+-Transporting Lysosomal-Interacting Protein 2 antibodyAnti-Er-Localized Type I Transmembrane Adapter antibodyAnti-Embryonic Liver Differentiation Factor 10 antibodyAnti-N14f antibodyAnti-Renin/Prorenin Receptor antibodyAnti-Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 antibodyAnti-Atp6m8-9 antibodyAnti-V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment antibodyAnti-ATP6AP2 antibodyAnti-ATP6IP2 antibodyAnti-CAPER antibodyAnti-ELDF10 antibodyAnti-HT028 antibodyAnti-MSTP009 antibodyAnti-PSEC0072 antibody |
Information sourced from Uniprot.org
