| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP2C2 (10-60 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
ATP2C2 |
| Gene ID: |
9914 |
| Uniprot ID: |
AT2C2_HUMAN |
| Immunogen Region: |
10-60 aa |
| Specificity: |
Specific for ATP2C2. |
| Immunogen: |
A synthetic peptide from aa region 10-60 of human ATP2C2 conjugated to blue carrier protein was used as the antigen. |
| Function | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus. |
| Protein Name | Calcium-Transporting Atpase Type 2c Member 2Atpase 2c2Ca(2+/Mn(2+-Atpase 2c2Secretory Pathway Ca(2+-Transporting Atpase Type 2Spca2 |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinCell MembraneBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Calcium-Transporting Atpase Type 2c Member 2 antibodyAnti-Atpase 2c2 antibodyAnti-Ca(2+/Mn(2+-Atpase 2c2 antibodyAnti-Secretory Pathway Ca(2+-Transporting Atpase Type 2 antibodyAnti-Spca2 antibodyAnti-ATP2C2 antibodyAnti-KIAA0703 antibodyAnti-SPCA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
