| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATL1 (1-280) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATL1 |
| Gene ID: |
51062 |
| Uniprot ID: |
ATLA1_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATL1 (NP_056999.2). |
| Immunogen Sequence: |
MAKNRRDRNSWGGFSEKTYE WSSEEEEPVKKAGPVQVLIV KDDHSFELDETALNRILLSE AVRDKEVVAVSVAGAFRKGK SFLMDFMLRYMYNQESVDWV GDYNEPLTGFSWRGGSERET TGIQIWSEIFLINKPDGKKV AVLLMDTQGTFDSQSTLRDS ATVFALSTMISSIQVYNLSQ NVQEDDLQHLQLFTEYGRLA MEETFLKPFQSLIFLVRDWS FPYEFSYGADGGAKFLEKR |
| Tissue Specificity | Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). |
| Function | GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. |
| Protein Name | Atlastin-1Brain-Specific Gtp-Binding ProteinGtp-Binding Protein 3Gbp-3Hgbp3Guanine Nucleotide-Binding Protein 3Spastic Paraplegia 3 Protein A |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCell ProjectionAxonLocalizes To Endoplasmic Reticulum Tubular Network |
| Alternative Antibody Names | Anti-Atlastin-1 antibodyAnti-Brain-Specific Gtp-Binding Protein antibodyAnti-Gtp-Binding Protein 3 antibodyAnti-Gbp-3 antibodyAnti-Hgbp3 antibodyAnti-Guanine Nucleotide-Binding Protein 3 antibodyAnti-Spastic Paraplegia 3 Protein A antibodyAnti-ATL1 antibodyAnti-GBP3 antibodyAnti-SPG3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
