| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATG4C (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATG4C |
| Gene ID: |
84938 |
| Uniprot ID: |
ATG4C_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ATG4C (NP_116241.2). |
| Immunogen Sequence: |
MEATGTDEVDKLKTKFISAW NNMKYSWVLKTKTYFSRNSP VLLLGKCYHFKYEDEDKTLP AESGCTIEDHVIAGNVEEFR KDFISRIWLTYREEFPQIEG SALTTDCGWGCTLRTGQMLL AQGLILHFLGRAWTWPDALN IENSDSESWTSHTVKKFTAS FEASLSGEREFKTPTISLKE TIGKYSDDHEMRNEVYHRKI |
| Function | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy. |
| Protein Name | Cysteine Protease Atg4cAut-Like 3 Cysteine EndopeptidaseAutophagy-Related Cysteine Endopeptidase 3Autophagin-3Autophagy-Related Protein 4 Homolog CHsapg4c |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Cysteine Protease Atg4c antibodyAnti-Aut-Like 3 Cysteine Endopeptidase antibodyAnti-Autophagy-Related Cysteine Endopeptidase 3 antibodyAnti-Autophagin-3 antibodyAnti-Autophagy-Related Protein 4 Homolog C antibodyAnti-Hsapg4c antibodyAnti-ATG4C antibodyAnti-APG4C antibodyAnti-AUTL1 antibodyAnti-AUTL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
