| Function | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics.this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
| Protein Name | Alpha-Tubulin N-Acetyltransferase 1Alpha-TatAlpha-Tat1TatAcetyltransferase Mec-17 Homolog |
| Database Links | Reactome: R-HSA-5617833 |
| Cellular Localisation | CytoplasmMembraneClathrin-Coated PitCell JunctionFocal AdhesionCell ProjectionAxonCytoskeletonSpindle |
| Alternative Antibody Names | Anti-Alpha-Tubulin N-Acetyltransferase 1 antibodyAnti-Alpha-Tat antibodyAnti-Alpha-Tat1 antibodyAnti-Tat antibodyAnti-Acetyltransferase Mec-17 Homolog antibodyAnti-ATAT1 antibodyAnti-C6orf134 antibodyAnti-MEC17 antibodyAnti-Nbla00487 antibody |
Information sourced from Uniprot.org
