| Function | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| Protein Name | Agouti-Signaling ProteinAspAgouti Switch Protein |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Agouti-Signaling Protein antibodyAnti-Asp antibodyAnti-Agouti Switch Protein antibodyAnti-ASIP antibodyAnti-AGTI antibodyAnti-AGTIL antibodyAnti-ASP antibody |
Information sourced from Uniprot.org
