| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel. |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. |
| Protein Name | Acid-Sensing Ion Channel 3Asic3Hasic3Amiloride-Sensitive Cation Channel 3Neuronal Amiloride-Sensitive Cation Channel 3Testis Sodium Channel 1Htnac1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell Surface Expression May Be Stabilized By Interaction With Lin7b And Cytoplasmic Retention By Interaction With Dlg4In Part Cytoplasmic In Cochlea Cells |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 3 antibodyAnti-Asic3 antibodyAnti-Hasic3 antibodyAnti-Amiloride-Sensitive Cation Channel 3 antibodyAnti-Neuronal Amiloride-Sensitive Cation Channel 3 antibodyAnti-Testis Sodium Channel 1 antibodyAnti-Htnac1 antibodyAnti-ASIC3 antibodyAnti-ACCN3 antibodyAnti-SLNAC1 antibodyAnti-TNAC1 antibody |
Information sourced from Uniprot.org
