| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties. |
| Protein Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Brain Sodium ChannelAmiloride-Sensitive Brain Sodium Channel 2Amiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-RNO-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 2 antibodyAnti-Asic2 antibodyAnti-Amiloride-Sensitive Brain Sodium Channel antibodyAnti-Amiloride-Sensitive Brain Sodium Channel 2 antibodyAnti-Amiloride-Sensitive Cation Channel 1 - Neuronal antibodyAnti-Amiloride-Sensitive Cation Channel Neuronal 1 antibodyAnti-Brain Sodium Channel 1 antibodyAnti-Bnc1 antibodyAnti-Bnac1 antibodyAnti-Mammalian Degenerin Homolog antibodyAnti-Mdeg antibodyAnti-Asic2 antibodyAnti-Accn1 antibodyAnti-Bnac1 antibodyAnti-Mdeg antibody |
Information sourced from Uniprot.org
