| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASB4 |
| Gene ID: | 51666 |
| Uniprot ID: | ASB4_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1). |
| Immunogen Sequence: | MDGTTAPVTKSGAAKLVKRN FLEALKSNDFGKLKAILIQR QIDVDTVFEVEDENMVLASY KQGYWLPSYKLKSSWATGLH LSVLFGHVECLLVLLDHNAT INCRPNGKTPLHVACEMANV DCVKILCDRGAKLNCYSLSG HTALHFCTTPSSILCAKQLV WRGANVNMKTNNQDEETPLH TAAHFGLSELVAFYVEHGAI VDSVNAHMETPLAIAAYWAL RFKEQEYSTEHHLVCRMLL |
| Post Translational Modifications | Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation. |
| Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. |
| Protein Name | Ankyrin Repeat And Socs Box Protein 4Asb-4 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Socs Box Protein 4 antibodyAnti-Asb-4 antibodyAnti-ASB4 antibody |
Information sourced from Uniprot.org