| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARS2 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SRRT |
| Gene ID: |
51593 |
| Uniprot ID: |
SRRT_HUMAN |
| Specificity: |
Specific for ARS2. |
| Immunogen: |
A synthetic peptide from human ARS2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse. |
| Function | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA).however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. |
| Protein Name | Serrate Rna Effector Molecule HomologArsenite-Resistance Protein 2 |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPredominantly NuclearShuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent Way |
| Alternative Antibody Names | Anti-Serrate Rna Effector Molecule Homolog antibodyAnti-Arsenite-Resistance Protein 2 antibodyAnti-SRRT antibodyAnti-ARS2 antibodyAnti-ASR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
