| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Arrestin domain-containing protein 3 (365-414 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARRDC3 |
| Gene ID: | 57561 |
| Uniprot ID: | ARRD3_HUMAN |
| Immunogen Region: | 365-414 aa |
| Specificity: | ARRDC3 Polyclonal Antibody detects endogenous levels of ARRDC3 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ARRDC3 at the amino acid range 365-414 |
| Function | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. |
| Protein Name | Arrestin Domain-Containing Protein 3Tbp-2-Like Inducible Membrane ProteinTlimp |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideLysosomeEndosomeEarly EndosomeAssociated With Plasma MembraneAs Well As With Endosomes And Lysosomes During Endocytosis |
| Alternative Antibody Names | Anti-Arrestin Domain-Containing Protein 3 antibodyAnti-Tbp-2-Like Inducible Membrane Protein antibodyAnti-Tlimp antibodyAnti-ARRDC3 antibodyAnti-KIAA1376 antibody |
Information sourced from Uniprot.org
