| Short Description : | Rabbit polyclonal anti-cAMP-regulated phosphoprotein 19 (1-50 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPP19 |
| Gene ID: | 10776 |
| Uniprot ID: | ARP19_HUMAN |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid range 1-50 |
| Immunogen Region: | 1-50 aa |
| Specificity: | ARP19 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| Protein Name | Camp-Regulated Phosphoprotein 19Arpp-19 |
| Database Links | Reactome: R-HSA-2465910 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Camp-Regulated Phosphoprotein 19 antibodyAnti-Arpp-19 antibodyAnti-ARPP19 antibody |
Information sourced from Uniprot.org
