| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Actin-related protein 2/3 complex subunit 5 (58-108 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARPC5 |
| Gene ID: | 10092 |
| Uniprot ID: | ARPC5_HUMAN |
| Immunogen Region: | 58-108 aa |
| Specificity: | This antibody detects endogenous levels of ARPC5 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human ARPC5 at the amino acid range 58-108 |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 5 Arp2/3 Complex 16 Kda Subunit P16-Arc |
| Database Links | Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-5663213 Reactome: R-HSA-6798695 Reactome: R-HSA-8856828 Reactome: R-HSA-9664422 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Projection Nucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 5 antibody Anti-Arp2/3 Complex 16 Kda Subunit antibody Anti-P16-Arc antibody Anti-ARPC5 antibody Anti-ARC16 antibody |
Information sourced from Uniprot.org