| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARPC3 (1-178) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARPC3 |
| Gene ID: |
10094 |
| Uniprot ID: |
ARPC3_HUMAN |
| Immunogen Region: |
1-178 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human ARPC3 (NP_001265485.1). |
| Immunogen Sequence: |
MPAYHSSLMDPDTKLIGNMA LLPIRSQFKGPAPRETKDTD IVDEAIYYFKANVFFKNYEI KNEADRTLIYITLYISECLK KLQKCNSKSQGEKEMYTLGI TNFPIPGEPGFPLNAIYAKP ANKQEDEVMRAYLQQLRQET GLRLCEKVFDPQNDKPSKWW TCFVKRQFMNKSLSGPGQ |
| Function | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
| Protein Name | Actin-Related Protein 2/3 Complex Subunit 3Arp2/3 Complex 21 Kda SubunitP21-Arc |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-3928662Reactome: R-HSA-5663213Reactome: R-HSA-8856828Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionNucleus |
| Alternative Antibody Names | Anti-Actin-Related Protein 2/3 Complex Subunit 3 antibodyAnti-Arp2/3 Complex 21 Kda Subunit antibodyAnti-P21-Arc antibodyAnti-ARPC3 antibodyAnti-ARC21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
