| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-BRCAA1 (Internal Region) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARID4B |
| Gene ID: | 51742 |
| Uniprot ID: | ARI4B_HUMAN |
| Immunogen Region: | Internal Region |
| Specificity: | Reacts with an internal region of the 136 kDa human, mouse and rat BRCAA1 protein. |
| Immunogen: | Synthetic peptide corresponding to amino acids from an internal sequence of the humanBRCAA1 protein |
| Function | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor. |
| Protein Name | At-Rich Interactive Domain-Containing Protein 4b Arid Domain-Containing Protein 4b 180 Kda Sin3-Associated Polypeptide Sin3-Associated Polypeptide P180 Breast Cancer-Associated Antigen Brcaa1 Histone Deacetylase Complex Subunit Sap180 Retinoblastoma-Binding Protein 1-Like 1 |
| Database Links | Reactome: R-HSA-3214815 Reactome: R-HSA-427413 Reactome: R-HSA-9679191 |
| Cellular Localisation | Nucleus Cytoplasm Cytoplasmic In Breast Cancer Cells |
| Alternative Antibody Names | Anti-At-Rich Interactive Domain-Containing Protein 4b antibody Anti-Arid Domain-Containing Protein 4b antibody Anti-180 Kda Sin3-Associated Polypeptide antibody Anti-Sin3-Associated Polypeptide P180 antibody Anti-Breast Cancer-Associated Antigen Brcaa1 antibody Anti-Histone Deacetylase Complex Subunit Sap180 antibody Anti-Retinoblastoma-Binding Protein 1-Like 1 antibody Anti-ARID4B antibody Anti-BRCAA1 antibody Anti-RBBP1L1 antibody Anti-RBP1L1 antibody Anti-SAP180 antibody |
Information sourced from Uniprot.org