| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rho guanine nucleotide exchange factor 4 (270-350 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARHGEF4 |
| Gene ID: |
50649 |
| Uniprot ID: |
ARHG4_HUMAN |
| Immunogen Region: |
270-350 aa |
| Specificity: |
ARHG4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 4Apc-Stimulated Guanine Nucleotide Exchange Factor 1AsefAsef1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Isoform 3: CytoplasmCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideAssociated With Membrane Ruffles |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 4 antibodyAnti-Apc-Stimulated Guanine Nucleotide Exchange Factor 1 antibodyAnti-Asef antibodyAnti-Asef1 antibodyAnti-ARHGEF4 antibodyAnti-KIAA1112 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
