| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Rho GTPase-activating protein 26 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ARHGAP26 |
| Gene ID: | 23092 |
| Uniprot ID: | RHG26_HUMAN |
| Specificity: | This antibody detects endogenous levels of GRAF at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human GRAF |
| Function | GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Isoform 2: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins. |
| Protein Name | Rho Gtpase-Activating Protein 26Gtpase Regulator Associated With Focal Adhesion KinaseGraf1Oligophrenin-1-Like ProteinRho-Type Gtpase-Activating Protein 26 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | Isoform 2: Endosome MembraneColocalized With Rab8aRab8b And Rab10 On Endosomal TubulesCytoplasmCell JunctionFocal AdhesionCytoskeletonColocalizes With Actin Stress Fibers And Cortical Actin Structures |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 26 antibodyAnti-Gtpase Regulator Associated With Focal Adhesion Kinase antibodyAnti-Graf1 antibodyAnti-Oligophrenin-1-Like Protein antibodyAnti-Rho-Type Gtpase-Activating Protein 26 antibodyAnti-ARHGAP26 antibodyAnti-GRAF antibodyAnti-KIAA0621 antibodyAnti-OPHN1L antibody |
Information sourced from Uniprot.org
