| Post Translational Modifications | Phosphorylated by ROCK, leading to activate the RacGAP activity. |
| Function | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. |
| Protein Name | Rho Gtpase-Activating Protein 24Filamin-A-Associated RhogapFilgapRac1- And Cdc42-Specific Gtpase-Activating Protein Of 72 KdaRc-Gap72Rho-Type Gtpase-Activating Protein 24Rhogap Of 73 KdaSarcoma Antigen Ny-Sar-88P73rhogap |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionAdherens JunctionFocal AdhesionCell ProjectionLocalizes To Actin Stress FibersIn Migrating CellsLocalizes To Membrane Lamellae And Protusions |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 24 antibodyAnti-Filamin-A-Associated Rhogap antibodyAnti-Filgap antibodyAnti-Rac1- And Cdc42-Specific Gtpase-Activating Protein Of 72 Kda antibodyAnti-Rc-Gap72 antibodyAnti-Rho-Type Gtpase-Activating Protein 24 antibodyAnti-Rhogap Of 73 Kda antibodyAnti-Sarcoma Antigen Ny-Sar-88 antibodyAnti-P73rhogap antibodyAnti-ARHGAP24 antibodyAnti-FILGAP antibody |
Information sourced from Uniprot.org
