| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ARHGAP22 (510-650) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARHGAP22 |
| Gene ID: |
58504 |
| Uniprot ID: |
RHG22_HUMAN |
| Immunogen Region: |
510-650 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 510-650 of human ARHGAP22 (NP_001242953.1). |
| Immunogen Sequence: |
NVPAPGLVPGIPSVASMAWS GASSSESSVGGSLSSCTACR ASDSSARSSLHTDWALEPSP LPSSSEDPKSLDLDHSMDEA GAGASNSEPSEPDSPTREHA RRSEALQGLVTELRAELCRQ RTEYERSVKRIEEGSADLRK R |
| Function | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter. |
| Protein Name | Rho Gtpase-Activating Protein 22Rho-Type Gtpase-Activating Protein 22 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmNucleusMainly CytoplasmicSome Fraction Is Nuclear |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 22 antibodyAnti-Rho-Type Gtpase-Activating Protein 22 antibodyAnti-ARHGAP22 antibodyAnti-RHOGAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
