| Function | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. |
| Protein Name | Rho Gtpase-Activating Protein 17Rho-Type Gtpase-Activating Protein 17Rhogap Interacting With Cip4 Homologs Protein 1Rich-1 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013423 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCell JunctionTight JunctionAssociates With Membranes And Concentrates At Sites Of Cell-Cell Contact |
| Alternative Antibody Names | Anti-Rho Gtpase-Activating Protein 17 antibodyAnti-Rho-Type Gtpase-Activating Protein 17 antibodyAnti-Rhogap Interacting With Cip4 Homologs Protein 1 antibodyAnti-Rich-1 antibodyAnti-ARHGAP17 antibodyAnti-RICH1 antibodyAnti-MSTP066 antibodyAnti-MSTP110 antibody |
Information sourced from Uniprot.org
