• STJ71831 (0. 05µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ71831 Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Anti-AREB6/ZEB1 antibody (Internal) (STJ71831)

SKU:
STJ71831-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-AREB6/ZEB1 (Internal) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.05-0.2µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ZEB1
Gene ID: 6935
Uniprot ID: ZEB1_HUMAN
Immunogen Region: Internal
Accession Number: NP_001121600.1; NP_110378.3
Specificity: This antibody is expected to recognize both reported isoforms (NP_001121600.1; NP_110378.3).
Immunogen Sequence: RPQIRQKIENKPLQE
Function Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region.
Protein Name Zinc Finger E-Box-Binding Homeobox 1
Nil-2-A Zinc Finger Protein
Negative Regulator Of Il2
Transcription Factor 8
Tcf-8
Database Links Reactome: R-HSA-6785807
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Zinc Finger E-Box-Binding Homeobox 1 antibody
Anti-Nil-2-A Zinc Finger Protein antibody
Anti-Negative Regulator Of Il2 antibody
Anti-Transcription Factor 8 antibody
Anti-Tcf-8 antibody
Anti-ZEB1 antibody
Anti-AREB6 antibody
Anti-TCF8 antibody

Information sourced from Uniprot.org

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