| Host: | Rabbit |
| Applications: | ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Bovine/Mouse/Rat/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-AQP9 (250-294) is suitable for use in ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.8 µg/µl |
| Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 ICC: 1:100 IF: 1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Aqp9 |
| Gene ID: | 65054 |
| Uniprot ID: | AQP9_RAT |
| Immunogen Region: | 250-294 |
| Immunogen: | Synthetic peptide taken within amino acid region 250-294 on rat Aquaporin 9 protein. |
| Tissue Specificity | Detected in testis and liver. Detected in immature spermatocytes and in interstitial Leydig cells. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium. |
| Protein Name | Aquaporin-9 Aqp-9 Aquaglyceroporin-9 |
| Database Links | Reactome: R-RNO-432030 Reactome: -RNO-432047 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Functions At The Hepatocyte Basolateral Membrane |
| Alternative Antibody Names | Anti-Aquaporin-9 antibody Anti-Aqp-9 antibody Anti-Aquaglyceroporin-9 antibody Anti-Aqp9 antibody Anti-Aqp9l antibody |
Information sourced from Uniprot.org