| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AQP9 (200-250 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
AQP9 |
| Gene ID: |
366 |
| Uniprot ID: |
AQP9_HUMAN |
| Immunogen Region: |
200-250 aa |
| Specificity: |
Specific for AQP9. |
| Immunogen: |
A synthetic peptide from mouse Aquaporin 9 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis. It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines. AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity. It is also permeable to H2O2 in vivo. Could also be permeable to ammonium. |
| Protein Name | Aquaporin-9Aqp-9Aquaglyceroporin-9Small Solute Channel 1 |
| Database Links | Reactome: R-HSA-432030Reactome: R-HSA-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneFunctions At The Hepatocyte Basolateral Membrane |
| Alternative Antibody Names | Anti-Aquaporin-9 antibodyAnti-Aqp-9 antibodyAnti-Aquaglyceroporin-9 antibodyAnti-Small Solute Channel 1 antibodyAnti-AQP9 antibodyAnti-SSC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
