| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5087RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AQP5 |
| Gene ID: |
362 |
| Uniprot ID: |
AQP5_HUMAN |
| Immunogen Region: |
165-265 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 165-265 of human AQP5. (NP_001642.1). |
| Immunogen Sequence: |
IGLSVTLGHLVGIYFTGCSM NPARSFGPAVVMNRFSPAHW VFWVGPIVGAVLAAILYFYL LFPNSLSLSERVAIIKGTYE PDEDWEEQREERKKTMELTT R |
| Tissue Specificity | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. |
| Protein Name | Aquaporin-5Aqp-5 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneHypotonicity Increases Location At The Cell MembranePhosphorylation Decreases Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Aquaporin-5 antibodyAnti-Aqp-5 antibodyAnti-AQP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
