| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AQP11 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
AQP11 |
| Gene ID: |
282679 |
| Uniprot ID: |
AQP11_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for AQP11. |
| Immunogen: |
A synthetic peptide from internal region of human Aquaporin 11 (AQP11) conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Not glycosylated. |
| Function | Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development. |
| Protein Name | Aquaporin-11Aqp-11 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneCell MembraneLocalizes Mainly To The Periphery Of Lipid DropletsLocalizes To Cytoplasmic Vesicles In Maturing SpermatozoaIt Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes |
| Alternative Antibody Names | Anti-Aquaporin-11 antibodyAnti-Aqp-11 antibodyAnti-AQP11 antibodyAnti-AQPX1 antibodyAnti-PSEC0027 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
