• Immunohistochemistry of rat kidney with Anti-Aquaporin 11 primary antibody (STJ500120) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-AQP11 antibody (140-190) (STJ500120)

SKU:
STJ500120-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AQP11 (140-190) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.57-0.67 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:500
ICC: 1:50
IF: 1:50
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Aqp11
Gene ID: 286758
Uniprot ID: AQP11_RAT
Immunogen Region: 140-190
Immunogen: Synthetic peptide taken within amino acid region 140-190 on Aquaporin 11 protein.
Tissue Specificity Expressed in retina specifically at retinal Mueller glial cells. Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells.
Post Translational Modifications Not glycosylated.
Function Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.
Protein Name Aquaporin-11
Aqp-11
Database Links Reactome: R-RNO-432047
Cellular Localisation Cytoplasmic Vesicle Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Membrane
Cytoplasm
Perinuclear Region
Localizes Mainly To The Periphery Of Lipid Droplets
It Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes
Alternative Antibody Names Anti-Aquaporin-11 antibody
Anti-Aqp-11 antibody
Anti-Aqp11 antibody

Information sourced from Uniprot.org

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