| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Aquaporin-11 (130-210 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AQP11 |
| Gene ID: |
282679 |
| Uniprot ID: |
AQP11_HUMAN |
| Immunogen Region: |
130-210 aa |
| Specificity: |
AQP11 Polyclonal Antibody detects endogenous levels of AQP11 protein. |
| Immunogen: |
Synthesized peptide derived from AQP11 at the amino acid range 130-210 |
| Post Translational Modifications | Not glycosylated. |
| Function | Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development. |
| Protein Name | Aquaporin-11Aqp-11 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell MembraneCytoplasmPerinuclear RegionLocalizes Mainly To The Periphery Of Lipid DropletsIt Accumulates Partly In Mitochondrial-Associated Endoplasmic Reticulum Membranes |
| Alternative Antibody Names | Anti-Aquaporin-11 antibodyAnti-Aqp-11 antibodyAnti-AQP11 antibodyAnti-AQPX1 antibodyAnti-PSEC0027 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
