| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AQP10 |
| Gene ID: |
89872 |
| Uniprot ID: |
AQP10_HUMAN |
| Immunogen Region: |
209-301 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 209-301 of human AQP10 (NP_536354.2). |
| Immunogen Sequence: |
CGIPLNPARDLGPRLFTYVA GWGPEVFSAGNGWWWVPVVA PLVGATVGTATYQLLVALHH PEGPEPAQDLVSAQHKASEL ETPASAQMLECKL |
| Tissue Specificity | Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum. Detected in subcutaneous adipose tissue. |
| Post Translational Modifications | N-glycosylation at Asn-133 increases the stability of the protein but has no effect on its activity. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Among aquaglyceroporins, it exhibits a unique pH-gated glycerol transport activity, being more active at acidic pH. It most likely plays a central role in the efflux of glycerol formed during triglyceride hydrolysis in adipocytes and in glycerol uptake by enterocytes, as both processes occur and are stimulated at acidic pH. |
| Protein Name | Aquaporin-10Aqp-10Aquaglyceroporin-10Small Intestine Aquaporin |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneLipid DropletDetected Around Lipid Droplets |
| Alternative Antibody Names | Anti-Aquaporin-10 antibodyAnti-Aqp-10 antibodyAnti-Aquaglyceroporin-10 antibodyAnti-Small Intestine Aquaporin antibodyAnti-AQP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
