| Tissue Specificity | Ubiquitous in fetal tissues. Expressed throughout the adult brain. |
| Post Translational Modifications | Ubiquitinated by TRIP12, leading to its degradation by the proteasome. |
| Function | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. |
| Protein Name | Nedd8-Activating Enzyme E1 Regulatory SubunitAmyloid Beta Precursor Protein-Binding Protein 1 - 59 KdaApp-Bp1Amyloid Protein-Binding Protein 1Proto-Oncogene Protein 1 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | Cell MembraneColocalizes With App In Lipid Rafts |
| Alternative Antibody Names | Anti-Nedd8-Activating Enzyme E1 Regulatory Subunit antibodyAnti-Amyloid Beta Precursor Protein-Binding Protein 1 - 59 Kda antibodyAnti-App-Bp1 antibodyAnti-Amyloid Protein-Binding Protein 1 antibodyAnti-Proto-Oncogene Protein 1 antibodyAnti-NAE1 antibodyAnti-APPBP1 antibodyAnti-HPP1 antibody |
Information sourced from Uniprot.org
