| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Apolipoprotein B receptor is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APOBR |
| Gene ID: |
55911 |
| Uniprot ID: |
APOBR_HUMAN |
| Specificity: |
APOBR Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. |
| Protein Name | Apolipoprotein B ReceptorApolipoprotein B-100 ReceptorApolipoprotein B-48 ReceptorApolipoprotein B48 ReceptorApob-48r |
| Database Links | Reactome: R-HSA-8964046 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBinds Monocyte-Macrophage MembraneThought To Be Anchored In The Membrane Through An Interaction With An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Apolipoprotein B Receptor antibodyAnti-Apolipoprotein B-100 Receptor antibodyAnti-Apolipoprotein B-48 Receptor antibodyAnti-Apolipoprotein B48 Receptor antibodyAnti-Apob-48r antibodyAnti-APOBR antibodyAnti-APOB48R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
