| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-APOB48R-Mouse (C-Term) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_612183.1 |
| Immunogen Sequence: |
QELQARLSQPKPQ |
| Post Translational Modifications | There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. |
| Protein Name | Apolipoprotein B ReceptorApolipoprotein B-100 ReceptorApolipoprotein B48 ReceptorApob-48r |
| Database Links | Reactome: R-MMU-8964046 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBinds Monocyte-Macrophage MembraneThought To Be Anchored In The Membrane Through An Interaction With An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Apolipoprotein B Receptor antibodyAnti-Apolipoprotein B-100 Receptor antibodyAnti-Apolipoprotein B48 Receptor antibodyAnti-Apob-48r antibodyAnti-Apobr antibodyAnti-Apob48r antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
