| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-APOB48R-Mouse (C-Term) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. WB: Preliminary experiments gave an approx. 37kDa band in Mouse and Rat Spleen lysates after 0.5µg/ml antibody staining. Please note that currently we cannot find an explanation in the lit |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | C-Term |
| Accession Number: | NP_612183.1 |
| Immunogen Sequence: | QELQARLSQPKPQ |
| Post Translational Modifications | There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. |
| Protein Name | Apolipoprotein B Receptor Apolipoprotein B-100 Receptor Apolipoprotein B48 Receptor Apob-48r |
| Database Links | Reactome: R-MMU-8964046 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Binds Monocyte-Macrophage Membrane Thought To Be Anchored In The Membrane Through An Interaction With An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Apolipoprotein B Receptor antibody Anti-Apolipoprotein B-100 Receptor antibody Anti-Apolipoprotein B48 Receptor antibody Anti-Apob-48r antibody Anti-Apobr antibody Anti-Apob48r antibody |
Information sourced from Uniprot.org