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Anti-APOA5 antibody [2G1H11/1F1E8] (STJ97835)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human ApoA-V expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Apolipoprotein A-V for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2G1H11/1F1E8 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOA5 |
| Gene ID | 116519 |
| Uniprot ID | APOA5_HUMAN |
| Immunogen | Purified recombinant fragment of human ApoA-V expressed in E. Coli. |
| Specificity | ApoA-V Monoclonal Antibody detects endogenous levels of ApoA-V protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin. |
| Protein Name | Apolipoprotein A-VApo-AvApoa-VApolipoprotein A5Regeneration-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-8963889Reactome: R-HSA-8963901 |
| Cellular Localisation | SecretedEarly EndosomeLate EndosomeGolgi ApparatusTrans-Golgi NetworkIn The Presence Of Sorl1Internalized To Early EndosomesSorted In A Retrograde Fashion To Late EndosomesFrom Which A Portion Is Sent To Lysosomes And DegradationAnother Portion Is Sorted To The Trans-Golgi Network |
| Alternative Antibody Names | Anti-Apolipoprotein A-V antibodyAnti-Apo-Av antibodyAnti-Apoa-V antibodyAnti-Apolipoprotein A5 antibodyAnti-Regeneration-Associated Protein 3 antibodyAnti-APOA5 antibodyAnti-RAP3 antibodyAnti-UNQ411 antibodyAnti-PRO773 antibody |
Information sourced from Uniprot.org