• Immunohistochemistry of rat tissue with Anti-APLNR primary antibody (STJ500108) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 20X.

Anti-APLNR antibody (330-377) (STJ500108)

SKU:
STJ500108-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-APLNR (330-377) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:50, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: APLNR
Gene ID: 187
Uniprot ID: APJ_HUMAN
Immunogen Region: 330-377
Immunogen: Synthetic peptide taken within amino acid region 330-377 rat Apelin receptor protein.
Tissue Specificity Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas. Expressed in glial cells, astrocytes and neuronal subpopulations. Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells.
Function Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.may be involved in the development of AIDS dementia.
Protein Name Apelin Receptor
Angiotensin Receptor-Like 1
G-Protein Coupled Receptor Apj
G-Protein Coupled Receptor Hg11
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
After Exposure To Apelin (Apln)
Internalized From The Cell Surface Into An Endosomal Recycling Compartment
From Where It Is Recycled To The Cell Membrane
After Exposure To Apelin Receptor Early Endogenous Ligand (Apela)
Alternative Antibody Names Anti-Apelin Receptor antibody
Anti-Angiotensin Receptor-Like 1 antibody
Anti-G-Protein Coupled Receptor Apj antibody
Anti-G-Protein Coupled Receptor Hg11 antibody
Anti-APLNR antibody
Anti-AGTRL1 antibody
Anti-APJ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance