Anti-API5 antibody (421-470 aa) (STJ91629)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human API-5 at the amino acid range 421-470
General Information
| Short Description | Rabbit polyclonal anti-Apoptosis inhibitor 5 (421-470 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | API5 |
| Gene ID | 8539 |
| Uniprot ID | API5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human API-5 at the amino acid range 421-470 |
| Immunogen Region | 421-470 aa |
| Specificity | API5 Polyclonal Antibody detects endogenous levels of API5 protein. |
Additional Info
| Post Translational Modifications | Acetylation at Lys-251 impairs antiapoptotic function. |
| Function | Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. |
| Protein Name | Apoptosis Inhibitor 5Api-5Antiapoptosis Clone 11 ProteinAac-11Cell Migration-Inducing Gene 8 ProteinFibroblast Growth Factor 2-Interacting FactorFifProtein Xagl |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmMainly NuclearCan Also Be CytoplasmicIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Apoptosis Inhibitor 5 antibodyAnti-Api-5 antibodyAnti-Antiapoptosis Clone 11 Protein antibodyAnti-Aac-11 antibodyAnti-Cell Migration-Inducing Gene 8 Protein antibodyAnti-Fibroblast Growth Factor 2-Interacting Factor antibodyAnti-Fif antibodyAnti-Protein Xagl antibodyAnti-API5 antibodyAnti-MIG8 antibody |
Information sourced from Uniprot.org