| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
APBB1IP |
| Gene ID: |
54518 |
| Uniprot ID: |
AB1IP_HUMAN |
| Immunogen Region: |
1-150 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human APBB1IP (NP_061916.3). |
| Immunogen Sequence: |
MGESSEDIDQMFSTLLGEMD LLTQSLGVDTLPPPDPNPPR AEFNYSVGFKDLNESLNALE DQDLDALMADLVADISEAEQ RTIQAQKESLQNQHHSASLQ ASIFSGAASLGYGTNVAATG ISQYEDDLPPPPADPVLDLP LPPPPPEPLS |
| Tissue Specificity | Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. |
| Function | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. |
| Protein Name | Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting ProteinApbb1-Interacting Protein 1Proline-Rich Evh1 Ligand 1Prel-1Proline-Rich Protein 73Rap1-Gtp-Interacting Adapter MoleculeRiamRetinoic Acid-Responsive Proline-Rich Protein 1Rarp-1 |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionLamellipodiumCell JunctionFocal AdhesionCytoplasmCytoskeletonColocalizes With Ena/Vasp Proteins At Lamellipodia Tips And Focal AdhesionsAnd F-Actin At The Leading EdgeAt The Membrane SurfaceAssociatesVia The Ph DomainPreferentially With The Inositol PhosphatesPtdins(5)P And Ptdins(3)PThis Binding Appears To Be Necessary For The Efficient Interaction Of The Ra Domain To Ras-Gtpases |
| Alternative Antibody Names | Anti-Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein antibodyAnti-Apbb1-Interacting Protein 1 antibodyAnti-Proline-Rich Evh1 Ligand 1 antibodyAnti-Prel-1 antibodyAnti-Proline-Rich Protein 73 antibodyAnti-Rap1-Gtp-Interacting Adapter Molecule antibodyAnti-Riam antibodyAnti-Retinoic Acid-Responsive Proline-Rich Protein 1 antibodyAnti-Rarp-1 antibodyAnti-APBB1IP antibodyAnti-PREL1 antibodyAnti-RARP1 antibodyAnti-RIAM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
