Anti-APBA1/MINT1 antibody (Internal) (STJ71157)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-APBA1/MINT1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 100kDa band observed in Human Brain (Cerebellum and Hippocampus) lysates (calculated MW of 92.9kDa according to NP_001154.2). Recommended concentration: 0.1-0.3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | APBA1 |
| Gene ID | 320 |
| Uniprot ID | APBA1_HUMAN |
| Accession Number | NP_001154.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | EASHPSQDGKRQYK |
Additional Info
| Function | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. |
| Protein Name | Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1Adapter Protein X11alphaNeuron-Specific X11 ProteinNeuronal Munc18-1-Interacting Protein 1Mint-1 |
| Database Links | Reactome: R-HSA-212676Reactome: R-HSA-6794361Reactome: R-HSA-9609736 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusOnly About 5% Of The Protein Is Located In The NucleusIsoform 2: Golgi Apparatus |
| Alternative Antibody Names | Anti-Amyloid-Beta A4 Precursor Protein-Binding Family A Member 1 antibodyAnti-Adapter Protein X11alpha antibodyAnti-Neuron-Specific X11 Protein antibodyAnti-Neuronal Munc18-1-Interacting Protein 1 antibodyAnti-Mint-1 antibodyAnti-APBA1 antibodyAnti-MINT1 antibodyAnti-X11 antibody |
Information sourced from Uniprot.org