Anti-AP-2 Alpha/Beta antibody (388-437 aa) (STJ91618)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human AP-2 at the amino acid range 388-437
General Information
| Short Description | Rabbit polyclonal anti-Transcription factor AP-2-alpha and Transcription factor AP-2-beta (388-437 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFAP2ATFAP2B |
| Gene ID | 70207021 |
| Uniprot ID | AP2A_HUMANAP2B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human AP-2 at the amino acid range 388-437 |
| Immunogen Region | 388-437 aa |
| Specificity | AP-2 Alpha/Beta Polyclonal Antibody detects endogenous levels of AP-2 Alpha/Beta protein. |
Additional Info
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Transcription Factor Ap-2-AlphaAp2-AlphaAp-2 Transcription FactorActivating Enhancer-Binding Protein 2-AlphaActivator Protein 2Ap-2 |
| Database Links | Reactome: R-HSA-3232118 P05549-1Reactome: R-HSA-8864260Reactome: R-HSA-8866904Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-8866911Reactome: R-HSA-8869496 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Alpha antibodyAnti-Ap2-Alpha antibodyAnti-Ap-2 Transcription Factor antibodyAnti-Activating Enhancer-Binding Protein 2-Alpha antibodyAnti-Activator Protein 2 antibodyAnti-Ap-2 antibodyAnti-TFAP2A antibodyAnti-AP2TF antibodyAnti-TFAP2 antibody |
Information sourced from Uniprot.org