| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Transcription Factor Ap-2-AlphaAp2-AlphaAp-2 Transcription FactorActivating Enhancer-Binding Protein 2-AlphaActivator Protein 2Ap-2 |
| Database Links | Reactome: R-HSA-3232118 P05549-1Reactome: R-HSA-8864260Reactome: R-HSA-8866904Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-8866911Reactome: R-HSA-8869496 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Alpha antibodyAnti-Ap2-Alpha antibodyAnti-Ap-2 Transcription Factor antibodyAnti-Activating Enhancer-Binding Protein 2-Alpha antibodyAnti-Activator Protein 2 antibodyAnti-Ap-2 antibodyAnti-TFAP2A antibodyAnti-AP2TF antibodyAnti-TFAP2 antibody |
Information sourced from Uniprot.org
