| Short Description : | Goat polyclonal antibody anti-ANTXR2/CMG2 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/IHC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.IHC: Paraffin embedded Human Liver and Kidney. Recommended concentration: 2.5µg/ml. |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ANTXR2 |
| Gene ID: | 118429 |
| Uniprot ID: | ANTR2_HUMAN |
| Accession Number: | NP_477520.2; NP_001139266.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | HEGLKLANEQIQK |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_477520.2; NP_001139266.1). |
| Function | Necessary for cellular interactions with laminin and the extracellular matrix. (Microbial infection) Receptor for the protective antigen (PA) of B.anthracis. Binding of PA leads to heptamerization of the receptor-PA complex. Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway. In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm. |
| Protein Name | Anthrax Toxin Receptor 2Capillary Morphogenesis Gene 2 ProteinCmg-2 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceIsoform 2: Endoplasmic Reticulum MembraneExpressed Predominantly Within The Endoplasmic Reticulum And Not At The Plasma MembraneIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Anthrax Toxin Receptor 2 antibodyAnti-Capillary Morphogenesis Gene 2 Protein antibodyAnti-Cmg-2 antibodyAnti-ANTXR2 antibodyAnti-CMG2 antibody |
Information sourced from Uniprot.org
