Anti-ANO9 antibody (481-530 aa) (STJ91605)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TM16J at the amino acid range 481-530
General Information
| Short Description | Rabbit polyclonal anti-Anoctamin-9 (481-530 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANO9 |
| Gene ID | 338440 |
| Uniprot ID | ANO9_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TM16J at the amino acid range 481-530 |
| Immunogen Region | 481-530 aa |
| Specificity | Anoctamin-9 Polyclonal Antibody detects endogenous levels of Anoctamin-9 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues by cAMP-dependent protein kinase A (PKA) which is essential for activation of its cation channel activity. |
| Function | PKA-activated nonselective cation channel. Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations. Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store. Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue. Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. |
| Protein Name | Anoctamin-9Transmembrane Protein 16jTumor Protein P53-Inducible Protein 5P53-Induced Gene 5 Protein |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumShows Predominantly An Intracellular Localization With A Weak Expression In The Cell Membrane |
| Alternative Antibody Names | Anti-Anoctamin-9 antibodyAnti-Transmembrane Protein 16j antibodyAnti-Tumor Protein P53-Inducible Protein 5 antibodyAnti-P53-Induced Gene 5 Protein antibodyAnti-ANO9 antibodyAnti-PIG5 antibodyAnti-TMEM16J antibodyAnti-TP53I5 antibody |
Information sourced from Uniprot.org