Anti-Angiopoietin 2 antibody [R04-7E6] (STJA0034017)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Angiopoietin 2
General Information
| Short Description | Rabbit monoclonal anti-Angiopoietin 2 for use in WB and IHC-P in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-7E6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ANGPT2 |
| Gene ID | 285 |
| Uniprot ID | ANGP2_HUMAN |
| Immunogen | A synthetic peptide of human Angiopoietin 2 |
Additional Info
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. |
| Protein Name | Angiopoietin-2Ang-2 |
| Database Links | Reactome: R-HSA-210993 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Angiopoietin-2 antibodyAnti-Ang-2 antibodyAnti-ANGPT2 antibody |
Information sourced from Uniprot.org